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Table 2 Core elements of life steps and anticipated modifications

From: Adherence intervention for HIV-infected persons who use drugs: adaptation, open trial, and pilot randomized hybrid type 1 trial protocol

Module

Description

Anticipated modifications to life steps

Existing life steps protocol

Step 1: Education and introduction

Information about how medication adherence plays in successful treatment is provided. The aim is to increase knowledge and self-efficacy to influence treatment success and introduce problem-solving for medication adherence

Information regarding the physiological and psychosocial impact drug use has in PLWH, address impact on ART medications and increased HIV transmission

Step 2: Transportation to appointments

Problem-solving strategies, brief cognitive restructuring, and rehearsal techniques are provided to address transportation issues to prevent missed appointments with health care providers

No anticipated modifications

Step 3: Obtaining medications

Develop a plan for continues access to medications. Address concerns about patient’s privacy and confidentiality during interactions with the pharmacist

No anticipated modifications

Step 4: Communicating with health care providers

Brief cognitive techniques are suggested for irrational fears about asking questions

Address concerns about drug use stigma; teach strategies for improving patient-provider relationship

Step 5: Coping with side effects

Learn to (a) pick a regimen with their doctor to minimize side effects; (b) re-interpret side effects as signs that medications are in their bloodstream and working; and (c) increase the salience of benefits of adherence

No anticipated modifications

Step 6: Formulating daily medication schedule

Patients complete a detailed map of an average day of pill-taking, specifying environmental and other cues for pill-taking throughout the day

Address challenges to maintaining the daily medication schedule during periods of intoxication

Step 7: Storing medications

Problem-solving techniques for storing medications when not at home

No anticipated modifications

Step 8: Cues for pill-taking

Taught how to use cues to remember to take pills (e.g., setting alarms, reminder system). Adaptive cognitions for adherence are rehearsed

No anticipated modifications

Step 9: Response to slips in adherence

Patients are taught how to handle slips and to avoid all-or-nothing thoughts. Cognitive techniques to cope with a lapse are discussed

Address how drug use may result in slips on adherence and how to minimize negative health outcomes

Step 10: Review

Review previous steps and address concerns

No anticipated modifications

Anticipated additional adherence-related modules to the life steps protocol (based on the syndemics model by Singer [1])

 Interpersonal factors

  Increasing social support and relationship stability

Brief training in interpersonal skills and strategies to help increase support networks and build healthy relationships

 Individual factors

  Psychiatric comorbidities

Participants will receive a list of local mental health and substance abuse treatment options

  HIV-related beliefs

Address interaction toxicity beliefs in regards to taking ARTs while using drugs and alcohol

 Environmental factors

  Stigma

Cognitive techniques will be provided to help participants cope with stigma related to HIV and drug use

  Access to services

Participants will receive a list of local resources to assist with housing, transportation, and food insecurity

Anticipated additional drug use modules to the life steps protocol (based on the FRAMES approach by Miller and Sanchez [23])

Personalized assessment and feedback

Participants will complete a baseline assessment of their drug use ad risk behaviors. Individualized feedback regarding personal risk or impairment will be given following assessment

Changing risk behaviors

Use of MI techniques to address drug use and other risk behaviors. Techniques include assessing stage of change, use of decisional balance, address discrepancies between personal goals and behavior, and emphasize that autonomy and responsibility for change is explicitly on the participant

Advice about changing

Advice about reducing or stopping drug use will be given to the participant in a nonjudgmental manner

Treatment options

A menu of self-directed change options and treatment alternatives will be offered to the participant

Empathic counseling

The clinician will show warmth, respect, and understanding towards the participant

Self-efficacy for change

Self-efficacy to change drug use will be engendered in the participant to encourage change