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Table 4 Comparison of groups on primary and secondary outcomes at 3-month follow-up: completers only

From: A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial

  Dependent variable
Days used Penn total SD work SD Social life SD family CGI HAM-A HAM-D
Time period (reference: baseline; type III SS p-value) 0.007 < 0.001 0.011 < 0.001 < 0.001 0.001 0.002 < 0.001
 6 week follow-up − 3.223*** (1.043) − 9.070*** (1.908) − 2.590** (1.050) − 4.060*** (1.009) − 3.383*** (0.978) − 1.013** (0.415) − 3.332* (1.953) − 2.444* (1.333)
 3 month follow-up − 2.318** (0.982) − 12.545*** (1.785) − 2.761*** (0.982) − 5.580*** (0.948) − 5.322*** (0.912) − 1.631*** (0.396) − 6.770*** (1.850) − 6.073*** (1.288)
Treatment group (reference: control; type III SS p-value) 0.256 0.297 0.152 0.990 0.918 0.900 0.720 0.856
 Intervention 1.342 (1.163) − 2.533 (2.392) 1.652 (1.128) − 0.013
1.015)
− 0.114 (1.106) − 0.060 (0.456) − 1.009 (2.792) 0.305 (1.666)
Age at baseline (type III SS p-value) 0.866 0.899 0.834 0.972 0.527 0.874 0.105 0.021
  0.010 (0.056) 0.016 (0.126) − 0.011(0.052) − 0.002 (0.043) − 0.035 (0.055) − 0.003 (0.021) 0.265 (0.159) 0.212** (0.088)
CGI-severity at baseline (type III SS p-value) 0.060 0.455 0.321 0.418 0.924 N/A 0.067 0.139
  0.924* (0.476) − 1.002 (1.325) − 0.564 (0.560) − 0.377 (0.459) − 0.056 (0.581)   3.163* (1.671) 1.411 (0.932)
Number of days in past 2 weeks using meth at baseline (ttype III SS p-value) N/A 0.991 0.173 0.050 0.138 0.009 0.564 0.925
   − 0.003 (0.280) 0.167 (0.120) 0.201** (0.099) 0.188 (0.124) 0.107*** (0.039) 0.205 (0.353) − 0.019 (0.198)
Time period by treatment group interaction (reference: baseline control; type III SS p-value) 0.002 0.230 0.531 0.753 0.948 0.171 0.049 0.660
 6 week follow-up Intervention − 4.783*** (1.550) 2.041 (2.833) − 0.603 (1.543) − 0.249 (1.483) 0.128 (1.436) − 1.123* (0.624) − 5.460* (2.937) − 1.817 (2.005)
 3 month follow-up Intervention − 4.626*** (1.463) 4.601* (2.661) − 1.628 (1.453) 0.802 (1.403) 0.433 (1.349) − 0.813 (0.586) − 6.452** (2.732) − 0.594
(1.886)
Constant 3.232 (3.134) 27.087*** (7.127) 7.266** (2.999) 7.905*** (2.466) 8.033** (3.103) 4.353*** (0.815) − 6.052 (8.957) (4.983) − 1.249
Observations 113 113 111 111 111 111 111 110
Log Likelihood − 297.348 − 367.367 − 289.208 − 280.067 − 285.397 − 196.906 − 369.688 − 320.790
Akaike Inf. Crit. 614.695 756.734 600.417 582.133 592.794 413.812 761.376 663.580
Bayesian Inf. Crit. 641.235 785.822 629.292 611.008 621.668 440.160 790.251 692.346
  1. Linear mixed-effects model; p-values entered in italic text; all other values are coefficients (standard error) unless otherwise stated
  2. *p < 0.1; **p < 0.05; ***p < 0.01