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Table 1 LINC-II eligibility criteria

From: Design of a randomized controlled trial to Link Infectious and Narcology Care (LINC-II) in St. Petersburg, Russia

Inclusion criteriaExclusion criteria
Age 18 years or olderNot fluent in Russian
HIV-positiveCognitive impairment precluding informed consent
Hospitalized at narcology hospitalBreastfeeding or being pregnant
History of injection drug useART use in the past 30 days prior to hospitalization
Provision of two contacts to assist with follow-upAcute severe psychiatric illness (i.e., answered yes to any of the following: past three month active hallucinations; mental health symptoms prompting a visit to the emergency room or hospital; mental health medication changes due to worsening symptoms; presence of suicidal ideations)
Address within St. Petersburg or districts within 100 km of St. PetersburgKnown history of liver failure
Possession of a home or mobile phoneKnown hypersensitivity to naltrexone
Ability and willingness to comply with all study protocols and proceduresAspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 5 times the upper limit of normal
Severe thrombocytopenia
Known coagulation disorder/taking anticoagulation medications
Body habitus that precludes intramuscular injection (e.g., BMI < 17 or > 45)
Known history of Raynaud’s disease, Itsenko-Cushing syndrome, generalized mycoses, glaucoma, or osteoporosis
Planned surgeries in the next 12 months