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Table 4 Mean comparisons based on lifetime cannabis use disorder, cocaine use disorder, and major depressive disorder with neurocognitive (NC) functioning (N = 97)

From: Neurocognitive, psychiatric, and substance use characteristics in a diverse sample of persons with OUD who are starting methadone or buprenorphine/naloxone in opioid treatment programs

Neurocognitive domain

Diagnosis of cannabis use disorder

Diagnosis of cocaine use disorder

Diagnosis of major depressive disorder

 

Yes (n = 42)

No (n = 54)

  

Yes (n = 57)

No (n = 39)

  

Yes (n = 35)

No (n = 61)

  
 

M (SD)

M (SD)

t-test

Cohen’s d

M (SD)

M (SD)

t-test

Cohen’s d

M (SD)

M (SD)

t-test

Cohen’s d

Global NC functioning

42.7 (5.7)

40.7 (6.9)

− 1.5

0.31

42.1 (6.7)

40.8 (6.1)

− 1.0

0.20

39.9 (7.0)

42.5 (6.0)

1.9*

0.41

Executive functioning

45.6 (7.3)

42.1 (7.9)

− 2.3**

0.46

44.9 (8.1)

41.7 (6.9)

− 2.0*

0.42

41.6 (8.0)

44.7 (7.5)

1.9*

0.40

Learning

35.3 (9.1)

33.6 (7.3)

− 1.0

0.21

33.6 (7.8)

35.4 (9.0)

1.0

0.22

33.2 (7.7)

35.0 (8.6)

1.0

0.22

Memory

36.4 (8.1)

34.7 (9.3)

− 0.9

0.19

35.1 (8.5)

36.1 (9.3)

0.5

0.11

34.7 (8.7)

35.9 (8.9)

0.6

0.14

Attention/working memory

46.0 (9.9)

40.8 (8.6)

− 2.8***

0.57

45.3 (9.6)

39.8 (8.5)

− 2.9***

0.60

39.7 (9.2)

45.0 (9.2)

2.7***

0.58

Speed of information processing

47.9 (7.4)

48.2 (10.0)

0.1

0.03

48.7 (9.3)

47.1 (8.3)

− 0.9

0.18

46.0 (9.6)

49.2 (8.3)

1.7*

0.36

Motor skills

42.1 (9.5)

41.9 (11.0)

− 0.1

0.02

41.2 (10.5)

43.2 (10.1)

0.9

0.19

38.4 (9.4)

44.1 (10.3)

2.6**

0.57

Verbal fluency

45.7 (9.1)

43.8 (10.5)

− 1.5

0.19

46.0 (10.7)

42.6 (8.3)

− 1.7*

0.35

46.0 (10.9)

43.9 (9.3)

− 1.0

0.21

  1. Mean and Standard Deviations (M, SD) based on average T scores; Diagnosis assessed using the Composite Diagnostic Interview (CIDI); T-scores between 45 and 54 = average; T-scores between 40 and 44 = below average; T-scores < 40 = overall impaired; T = 35–39 mildly impaired; T = 30–34 mild-moderately impaired; T = 25–29 moderately impaired; T = 20–24 moderate-severely impaired; and T < 20 severely impaired
  2. *p < 0.10
  3. **p < 0.05
  4. ***p < 0.01