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Table 1 Search strategy

From: A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder

Medline (Ovid)

 1. Genome-Wide Association Study/

 2. Genotyping Techniques/

 3. Genome, Human/

 4. Genetic Variation/

 5. Genetics/ or exp human genetics/

 6. (Human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw,kf

 7. (GWS or GWAS or GWA).mp

 8. Genome wide.ti,ab,kw,kf

 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8

 10. Exp Opioid-Related Disorders/

 11. ((Opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw,kf

 12. Opiate Substitution Treatment/

 13. ((Opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw,kf

 14. Exp buprenorphine/ or exp naloxone/

 15. Exp Methadone/

 16. (Suboxone or methadone or buprenorphine or naloxone).ti,ab,kw,kf

 17. 10 or 11 or 12 or 13 or 14 or 15 or 16

 18. 9 and 17

 19. Limit 18 to humans

Web of science—All databases

 1. TS = (genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome)

 2. T S = ((opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*) NEAR/2 (overdose* or use* or using or misus* or abus* or dependence* or addict*))

 3. TS = ((treatment* or therap*) NEAR/2 (opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*)

 4. TS = (methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone)

 5. #3 or #4

 6. #1 and #2 and #

EMBASE (Ovid)

 1. Genome-Wide Association Study/

 2. Genotyping Techniques/

 3. Genome, Human/

 4. Genetic Variation/

 5. Genetics/ or exp human genetics/

 6. (Human* adj2 (genotyp* or genome* or genetic*)).ti,ab,kw

 7. (GWS or GWAS or GWA).mp

 8. Genome wide.ti,ab,kw

 9. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8

 10. Exp Opioid-Related Disorders/

 11. ((Opiate* or opioid* or heroin* or codeine* or dilaudid* or fentanyl* or narcotic* or drug* or substance*) adj2 (overdose* or use* or using or misuse* or abus* or dependence* or addict*)).ti,ab,kw

 12. Opiate Substitution Treatment/

 13. ((Opiate* or opioid*) adj2 (treatment* or therap*)).ti,ab,kw

 14. Exp buprenorphine/ or exp naloxone/

 15. Exp Methadone/

 16. (Suboxone or methadone or buprenorphine or naloxone).ti,ab,kw

 17. 10 or 11 or 12 or 13 or 14 or 15 or 16

 18. 9 and 17

 19. Limit 18 to human

CINAHL and Pre-CINAHL

 1. Genome-wide association study or genome-wide association or GWAS or GWA or genome wide or genome

 2. Opiate* or opioid* or heroin* or fentanyl* or narcotic* or drug* or substance*

 3. Overdose* or use* or using or misus* or abus* or dependence* or addict*

 4. S2 and S3

 5. Treatment* or therap*

 6. S5 and S2

 7. Methadone or buprenorphine or naloxone or naltrexone or heroin-assisted or suboxone

 8. S6 or S7

 9. S1 and S4 and S8

 10 .Limit to Human

GWAS Catalog—publications

 -Methadone

 -Opioid

 -Heroin

 -Drug abuse

GWAS Central—studies list

 -Methadone

 -Heroin

 -Opioid

 -Opiate

 -Addiction

 -Drug abuse

 -Opioid dependence

 -Opioid addiction

 -Fentanyl

NIH Database of genotypes and phenotypes

 -Search (opioid)

 -Search (heroin)