Table 3 Observed primary and secondary outcomes at the different timepoints

12.3 (6.75)

11.5 (4.14)

11.0 (4.71)

11.6 (5.23)

10.4 (4.89)

11.8 (4.80)

10.7 (6.26)

12.6 (5.98)

5.57 (3.36)

4.77 (2.92)

4.79 (3.24)

4.71 (2.79)

4.53 (2.46)

5.04 (3.08)

4.63 (3.46)

5.75 (3.45)

6.73 (4.21)

6.72 (3.24)

6.21 (3.33)

6.93 (4.16)

5.84 (2.89)

6.80 (3.74)

6.06 (2.95)

6.88 (3.65)

16.9 (2.59)

17.1 (1.91)

16.6 (1.91)

15.8 (2.51)

17.0 (1.97)

16.5 (2.43)

17.2 (1.83)

16.4 (2.60)

10.2 (4.52)

9.00 (4.84)

9.57 (5.46)

8.69 (4.82)

9.26 (4.43)

9.00 (5.45)

7.94 (4.06)

8.62 (6.33)

72.6 (10.5)

72.6 (10.5)

69.9 (8.88)

67.8 (11.8)

73.2 (10.2)

74.0 (9.76)

71.8 (10.2)

72.3 (12.0)

31.9 (12.7)

29.8 (13.1)

33.1 (11.5)

39.4 (14.6)

36.6 (11.0)

34.9 (12.2)

33.4 (12.4)

36.6 (14.2)

8.70 (8.46)

12.5 (7.74)

7.73 (6.96)

11.5 (9.91)

11.1 (8.88)

10.6 (8.00)

10.0 (7.60)

13.9 (10.6)

4.32 (4.04)

6.51 (5.94)

5.20 (5.94)

6.18 (7.03)

6.42 (6.41)

5.38 (5.76)

6.30 (7.09)

9.22 (8.63)

16.9 (7.83)

18.3 (6.25)

19.6 (9.36)

19.0 (9.62)

18.6 (9.48)

16.6 (8.02)

15.9 (9.05)

18.8 (10.1)

8.49 (2.01)

8.36 (1.71)

6.93 (4.27)

7.18 (2.86)

7.26 (3.12)

7.45 (3.05)

6.65 (3.03)

7.56 (2.89)

4.38 (1.52)

4.03 (1.50)

3.53 (1.88)

4.05 (1.50)

3.26 (2.08)

3.52 (1.70)

3.30 (2.08)

3.56 (2.01)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

1 (1.3)

0 (0)

1 (1.3)

0 (0)

0 (0)

2 (2.6)

3 (3.9)

4 (5.2)

9 (11.8)

8 (10.5)

13 (17.1)

5 (6.6)

9 (11.8)

5 (6.6)

10 (13.2)

6 (7.9)

12 (15.8)

7 (9.2)

13 (17.1)