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Table 2 Intervention details and safety

From: Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder

 

Index hospitalization before sOATa

Day 1

Day 2

Day 3

Short-Acting opioids

Median (IQR) MME per 24 h

Median (IQR) MME per 24 h

Median (IQR) MME per 24 h

Median (IQR) MME per 24 h

     All short-acting opioids

29 (3, 74)

200 (135, 303)

276 (180, 466)

320 (135, 400)

 

Cases administered (%)

Cases administered (%)

Cases administered (%)

Cases administered (%)

     Oxycodone IR

8 (34.8)

14 (60.9)

14 (60.9)

14 (60.9)

     Oxycodone ER

0 (0.0)

2 (8.7)

0 (0)

1 (4.3)

     Hydromorphone PO

5 (21.7)

9 (39.1)

8 (34.8)

6 (26.1)

     Hydromorphone IV

5 (21.7)

9 (39.1)

6 (26.1)

2 (8.7)

     Other short-acting opioidsb

2 (8.7)

1 (4.3)

1 (4.3)

1 (4.3)

Medications for OUD

Cases administered (%)

Cases administered (%)

Cases administered (%)

Cases administered (%)

     Buprenorphine

1 (4.3)

1 (4.3)

1 (4.3)

1 (4.3)

     Methadone

13 (56.5)

15 (65.2)

15 (65.2)

15 (65.2)

Non-Opioid adjuvants

Cases administered (%)

Cases administered (%)

Cases administered (%)

Cases administered (%)

     Opioid withdrawalc

9 (39.1)

13 (56.5)

14 (60.9)

14 (60.9)

     Gabapentinoids

8 (34.8)

13 (56.5)

14 (60.9)

14 (60.9)

     Benzodiazepines

7 (30.4)

9 (39.1)

9 (39.1)

8 (34.8)

     Barbiturates

1 (4.3)

1 (4.3)

1 (4.3)

1 (4.3)

     Non-benzodiazepine anxiolyticsd

4 (17.4)

4 (17.4)

4 (17.4)

4 (17.4)

     Anti-spasmodics

6 (26.1)

13 (56.5)

11 (47.8)

11 (47.8)

     NSAIDs or acetaminophen

20 (87.0)

19 (82.6)

19 (82.6)

20 (87.0)

Safety

No. (%)

No. (%)

No. (%)

No. (%)

Naloxone administrations

0 (0)

1 (4.3)

0 (0)

0 (0)

Sedation (RASSe ≤ − 3 or POSS‡ ≥ 3)

0 (0)

0 (0.0)

0 (0.0)

1 (4.3)

Falls

0 (0)

0 (0)

0 (0)

0 (0)

  1. a Median (IQR) hours before intervention: 21 (12.0, 43.0)
  2. b Morphine IV, fentanyl IV, remifentanil IV
  3. c Clonidine, ondansetron, or loperamide
  4. d Anti-psychotics or hydralazline
  5. e RASS Richmond Agitation Sedation scale, POSS Pasero Opioid-induced Sedation Scale, COWS Clinical Opiate Withdrawal scale