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Table 1 Laboratory and other diagnostic data for a 37-year-old man with severe alcohol use disorder admitted to the hospital for acute liver injury

From: Grayken lessons: between a rock and a hard place? A 37-year-old man with acute liver injury while enrolled in a managed alcohol program for severe alcohol use disorder

Liver enzymes and function tests (normal range)

During 5 years before hospital admissiona

Hospital Day 1

Hospital Day 2

Hospital Day 15

ALT (< 54 U/L)

45–256

171

141

91

AST (5–45 U/L)

54–126

836

631

162

ALP (38–150 U/L)

61

394

357

140

GGT (< 49 U/L)

27–93

3532

3008

845

Total Bilirubin (< 1 mg/dL)b

0.58

10.41

14.85

3.16

INR (0.8–1.2)

1.0

1.3

1.8

1.0

Other serology

 HCV antibody(+), viral load(−)

 Hemochromatosis: C282Y/H63D negative

Liver biopsy

 Primarily cholestatic injury, not in keeping with primary alcoholic hepatitis

 Moderate steatosis, mild active steatohepatitis, heavy iron staining

 Stage 3 (out of 4) fibrosis

MRCP

 No evidence of biliary obstruction

 Hepatic steatosis, smooth liver contour, no cirrhosis

  1. ALT Alanine transaminase, U/L units per litre, AST Aspartate transaminase, ALP Alkaline phosphatase, GGT gamma-glutamyl transferase, INR International Normalized Ratio, MRCP Magnetic resonance cholangiopancreatography
  2. aRange of values during 5 years, or single value if only one available
  3. bto convert bilirubin to umol/L, multiply these values by 17.1