Liver enzymes and function tests (normal range) | During 5Â years before hospital admissiona | Hospital Day 1 | Hospital Day 2 | Hospital Day 15 |
---|---|---|---|---|
ALT (< 54 U/L) | 45–256 | 171 | 141 | 91 |
AST (5–45 U/L) | 54–126 | 836 | 631 | 162 |
ALP (38–150 U/L) | 61 | 394 | 357 | 140 |
GGT (< 49 U/L) | 27–93 | 3532 | 3008 | 845 |
Total Bilirubin (< 1 mg/dL)b | 0.58 | 10.41 | 14.85 | 3.16 |
INR (0.8–1.2) | 1.0 | 1.3 | 1.8 | 1.0 |
Other serology | ||||
 HCV antibody(+), viral load(−) | ||||
 Hemochromatosis: C282Y/H63D negative | ||||
Liver biopsy | ||||
 Primarily cholestatic injury, not in keeping with primary alcoholic hepatitis | ||||
 Moderate steatosis, mild active steatohepatitis, heavy iron staining | ||||
 Stage 3 (out of 4) fibrosis | ||||
MRCP | ||||
 No evidence of biliary obstruction | ||||
 Hepatic steatosis, smooth liver contour, no cirrhosis |