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Table 3 Intention to Treat Comparison of Groups on Primary and Secondary Outcomes

From: A novel brief treatment for methamphetamine use disorders in South Africa: a randomised feasibility trial

  Dependent variable
Days used Penn total SD work SD social life SD family CGI HAM-A HAM-D
Time period (reference: baseline; type III SS p-value) 0.029 < 0.001 0.023 < 0.001 < 0.001 0.002 0.001 < 0.001
 6 week follow-up − 2.133** (0.830) − 5.067*** (1.523) − 1.367* (0.751) − 2.233*** (0.755) − 1.933*** (0.697) − 0.567* (0.312) − 2.533* (1.412) − 1.267 (0.952)
  3 month follow-up − 1.667** (0.830) − 9.367*** (1.523) − 2.067*** (0.751) − 4.133*** (0.755) − 3.900*** (0.697) − 1.133*** (0.312) − 5.633*** (1.412) − 4.100*** (0.952)
Treatment group (reference: control; type III SS p-value) 0.343 0.347 0.233 0.791 0.474 0.915 0.319 0.899
  Intervention 1.104 (1.155) − 2.020 (2.131) 1.129 (0.937) −  0.242 (0.909) − 0.645 (0.894) 0.041 (0.387) − 2.302 (2.458) 0.230 (1.575)
Age at baseline (type III SS p-value) 0.337 0.279 0.106 0.072 0.156 0.093 0.497 0.499
  − 0.070 (0.072) − 0.145 (0.133) − 0.089 (0.054) − 0.094* (0.051) − 0.076 (0.053) − 0.038* (0.022) 0.087 (0.167) 0.052 (0.105)
CGI-severity at baseline (type III SS p-value) 0.197 0.185 0.826 0.449 0.466 N/A 0.006 0.002
  0.660 (0.505) − 1.391 (1.037) − 0.094 (0.424) 0.305 (0.400) 0.303 (0.413)   3.489*** (1.225) 2.435*** (0.760)
Number of days in past 2 weeks using meth at baseline (type III SS p-value) N/A 0.651 0.191 0.774 0.992 0.013 0.381 0.496
   0.107 (0.236) 0.128 (0.097) − 0.026 (0.091) − 0.001 (0.094) 0.091** (0.036) 0.602** (0.265) 0.129 (0.167)
Time period by treatment group interaction (reference: baseline control; type III SS p-value) 0.013 0.169 0.786 0.386 0.672 0.283 0.312 0.529
 6 week follow-up Intervention − 2.767** (1.173) 0.667 (2.154) − 0.433 (1.063) − 0.567 (1.068) − 0.300 (0.985) − 0.667 (0.442) − 2.300 (1.997) − 1.433 (1.346)
 3 month follow-up Intervention − 3.267*** (1.173) 3.833* (2.154) − 0.733 (1.063) 0.900 (1.068) 0.567 (0.985) − 0.533 (0.442) − 2.900 (1.997) − 0.267 (1.346)
Constant 7.336** (3.618) 33.193*** (6.648) 8.201*** (2.730) 9.324*** (2.580) 9.194*** (2.655) 5.526*** (0.812) 12.418** (5.975) 9.780** (3.774)
Observations 180 180 180 180 180 180 180 180
Log Likelihood − 499.304 − 603.844 − 472.698 − 470.088 − 462.489 − 321.576 − 609.198 − 537.667
Akaike Inf. Crit. 1,018.608 1,229.687 967.396 962.175 946.978 663.153 1,238.396 1,095.333
Bayesian Inf. Crit. 1050.083 1264.245 1001.955 996.734 981.537 694.628 1269.870 1126.808
  1. Linear mixed-effects model; p-values entered in italic text; all other values are coefficients (standard error) unless otherwise stated
  2. *p < 0.1; **p < 0.05; ***p < 0.01