Articles

Prevalence of marijuana use in pregnant women with concurrent opioid use disorder or alcohol use in pregnancy

A quarter of pregnant women use alcohol, 6.5/1000 deliveries are affected by opioid use disorder (OUD), and the prevalence of cannabis use in pregnant women is increasing. However, marijuana co-exposure in pol...

Authors: Kimberly Page, Cristina Murray-Krezan, Lawrence Leeman, Mary Carmody, Julia M. Stephen and Ludmila N. Bakhireva

Electronic cigarettes as a harm reduction strategy among patients with COPD: protocol for an open-label two arm randomized controlled pilot trial

Smoking cessation is the most effective means of slowing the decline of lung function associated with chronic obstructive pulmonary disease (COPD). While effective smoking cessation treatments are available, t...

Authors: Elizabeth R. Stevens, Lei Lei, Charles M. Cleland, Mahathi Vojjala, Omar El-Shahawy, Kenneth I. Berger, Thomas R. Kirchner and Scott E. Sherman

A personalized biomedical risk assessment infographic for people who smoke with COPD: a qualitative study

Chronic obstructive pulmonary disease (COPD) causes 3 million deaths each year, yet 38% of COPD patients continue to smoke. Despite proof of effectiveness and universal guideline recommendations, smoking cessa...

Authors: Samir Gupta, Puru Panchal, Mohsen Sadatsafavi, Parisa Ghanouni, Don Sin, Smita Pakhale, Teresa To, Zafar Zafari and Laura Nimmon

Methadone initiation in a bridge clinic for opioid withdrawal and opioid treatment program linkage: a case report applying the 72-hour rule

In the United States, methadone for opioid use disorder (OUD) is limited to highly regulated opioid treatment programs (OTPs), rendering it inaccessible to many patients. The “72-hour rule” allows non-OTP prov...

Authors: Jordana Laks, Jessica Kehoe, Natalija M. Farrell, Miriam Komaromy, Jonathan Kolodziej, Alexander Y. Walley and Jessica L. Taylor

Rural opioid treatment program patient perspectives on take-home methadone policy changes during COVID-19: a qualitative thematic analysis

In the United States, methadone for opioid use disorder (OUD) is highly regulated. Federal agencies announced guidelines in March 2020 allowing for relaxation of take-home methadone dispensing at opioid treatm...

Authors: Ximena A. Levander, Kim A. Hoffman, John W. McIlveen, Dennis McCarty, Javier Ponce Terashima and P. Todd Korthuis

Opioid use disorder from poppy seed tea successfully treated with buprenorphine in primary care: a case report

Poppy seeds contain morphine and other opioid alkaloids and are commercially available in the United States. Users of poppy seed tea (PST) can consume several hundred morphine milligram equivalents per day, an...

Authors: Scott Hagan, Carol E. Achtmeyer, Carly Hood, Eric J. Hawkins and Emily C. Williams

A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder

Patients with opioid use disorder (OUD) display an interindividual variability in their response to medications for opioid use disorder (MOUD). A genetic basis may explain the variability in this response. How...

Authors: Caroul Chawar, Alannah Hillmer, Stephanie Sanger, Alessia D’Elia, Balpreet Panesar, Lucy Guan, Dave Xiaofei Xie, Nandini Bansal, Aamna Abdullah, Flavio Kapczinski, Guillaume Pare, Lehana Thabane and Zainab Samaan

The validation and reliability of a Japanese version of the Problematic Online Gaming Questionnaire (POGQ-J)

The Problematic Online Gaming Questionnaire (POGQ) is an 18-item self-rated measure designed to assess the degree of problematic online gaming. This study translated the POGQ into Japanese (POGQ-J) and examine...

Authors: Kazuya Inoue, Kengo Yokomitsu, Tomonari Irie, Makoto Matsuyama and Masanori Tanaka

Early innovations in opioid use disorder treatment and harm reduction during the COVID-19 pandemic: a scoping review

The COVID-19 pandemic has exerted a significant toll on the lives of people who use opioids (PWUOs). At the same time, more flexible regulations around provision of opioid use disorder (OUD) services have led ...

Authors: Noa Krawczyk, Adetayo Fawole, Jenny Yang and Babak Tofighi

Perspectives on extended-release naltrexone induction among patients living with HIV and opioid use disorder: a qualitative analysis

The CHOICES study randomized participants with HIV and opioid use disorder (OUD) to HIV clinic-based extended-release naltrexone (XR-NTX), which requires complete cessation of opioid use, versus treatment-as-u...

Authors: Kim A. Hoffman, Robin Baker, Laura C. Fanucchi, Paula J. Lum, Lynn E. Kunkel, Javier Ponce Terashima, Dennis McCarty, Petra Jacobs and P. Todd Korthuis

Feasibility and acceptability of electronic administration of patient reported outcomes using mHealth platform in emergency department patients with non-medical opioid use

The emergency department (ED) offers an important opportunity to identify patients with opioid use disorder (OUD) and initiate treatment. However, post-ED follow-up is challenging, and novel approaches to enha...

Authors: Kathryn Hawk, Caitlin Malicki, Jeremiah Kinsman, Gail D’Onofrio, Andrew Taylor and Arjun Venkatesh

Alcohol dependence in a community sample of Aboriginal and Torres Strait Islander Australians: harms, getting help and awareness of local treatments

Few studies have examined links between current alcohol dependence and specific harms among Indigenous Australians. We investigated these associations as well as help seeking for drinking, awareness of local t...

Authors: Teagan J. Weatherall, James H. Conigrave, Katherine M. Conigrave, Jimmy Perry, Scott Wilson, Robin Room, Tanya Chikritzhs and K. S. Kylie Lee

Neurocognitive, psychiatric, and substance use characteristics in a diverse sample of persons with OUD who are starting methadone or buprenorphine/naloxone in opioid treatment programs

Medications for opioid use disorder such as opioid agonist treatment (OAT, including methadone, buprenorphine) are the gold standard intervention for opioid use disorder (OUD). Persons with OUD have high rates...

Authors: Travis M. Scott, Julia Arnsten, James Patrick Olsen, Franchesca Arias, Chinazo O. Cunningham and Monica Rivera Mindt

Addressing complex pharmacy consultations: methods used to develop a person-centred intervention to highlight alcohol within pharmacist reviews of medications

Alcohol is challenging to discuss, and patients may be reluctant to disclose drinking partly because of concern about being judged. This report presents an overview of the development of a medications review i...

Authors: Jim McCambridge, Karl Atkin, Ranjita Dhital, Brent Foster, Brendan Gough, Mary Madden, Stephanie Morris, Ronan O’Carroll, Margaret Ogden, Anne Van Dongen, Sue White, Cate Whittlesea and Duncan Stewart

Project MIMIC (Maximizing Implementation of Motivational Incentives in Clinics): A cluster-randomized type 3 hybrid effectiveness-implementation trial

Opioid-related overdoses and harms have been declared a public health emergency in the United States, highlighting an urgent need to implement evidence-based treatments. Contingency management (CM) is one of t...

Authors: Sara J. Becker, Cara M. Murphy, Bryan Hartzler, Carla J. Rash, Tim Janssen, Mat Roosa, Lynn M. Madden and Bryan R. Garner

The impact of methamphetamine/amphetamine use on receipt and outcomes of medications for opioid use disorder: a systematic review

Methamphetamine/amphetamine use has sharply increased among people with opioid use disorder (OUD). It is therefore important to understand whether and how use of these substances may impact receipt of, and out...

Authors: Madeline C. Frost, Hannah Lampert, Judith I. Tsui, Matthew D. Iles-Shih and Emily C. Williams

An Ethnographic study of unhealthy alcohol use in a Danish Emergency Department

Emergency Departments (EDs) are important arenas for the detection of unhealthy substance use. Screening, Brief Intervention, and Referral to Treatment (SBIRT) for unhealthy alcohol use has been used in some E...

Authors: Ditte Maria Sivertsen, Ulrik Becker, Ove Andersen and Jeanette Wassar Kirk

A Descriptive analysis of urine drug screen results in patients with opioid use disorder managed in a primary care setting

Urine drug screening (UDS) is commonly used as part of treatment for opioid use disorder (OUD), including treatment with buprenorphine-naloxone for OUD in a primary care setting. Very little is known about th...

Authors: Halle G. Sobel, Jill S. Warrington, Samuel Francis-Fath, Abigail M. Crocker and Claudia A. Berger

Correction to: Reimagining brief interventions for alcohol: towards a paradigm fit for the twenty first century

Authors: Jim McCambridge

Care-engaged individuals with polysubstance use in Northeastern US are undertreated for methamphetamine use disorder: a retrospective cohort study

Stimulant use has increased across the US, with concomitant opioid and methamphetamine use doubling between 2011 and 2017. Shifting patterns of polysubstance use have led to rising psychostimulant-involved dea...

Authors: Mimi Yen Li, George A. Alba, Julian Mitton and Benjamin Bearnot

Integrating traditional practices and social network visualization to prevent substance use: study protocol for a randomized controlled trial among urban Native American emerging adults

Nonmedical use of prescription opioids (defined as taking opioid medications for hedonic effects or in a manner other than prescribed) and the use of heroin have emerged in recent years as major public health ...

Authors: Elizabeth J. D’Amico, Daniel L. Dickerson, Anthony Rodriguez, Ryan A. Brown, David P. Kennedy, Alina I. Palimaru, Carrie Johnson, Rosanna Smart, David J. Klein, Jennifer Parker, Keisha McDonald, Michael J. Woodward and Ninna Gudgell

Clinical leaders and providers’ perspectives on delivering medications for the treatment of opioid use disorder in Veteran Affairs’ facilities

Improving access to medication treatment of opioid use disorder (MOUD) is a national priority, yet common modifiable barriers (e.g., limited provider knowledge, negative beliefs about MOUD) often challenge imp...

Authors: Eric J. Hawkins, Anissa N. Danner, Carol A. Malte, Brittany E. Blanchard, Emily C. Williams, Hildi J. Hagedorn, Adam J. Gordon, Karen Drexler, Jennifer L. Burden, Jennifer Knoeppel, Aline Lott, George G. Sayre, Amanda M. Midboe and Andrew J. Saxon

Preliminary study of alcohol problem severity and response to brief intervention

Findings have been mixed as to whether brief intervention (BI) is appropriate and effective for individuals with more severe alcohol use problems. Motivation to change drinking has been supported as a mechanis...

Authors: Lindsay R. Meredith, Erica N. Grodin, Mitchell P. Karno, Amanda K. Montoya, James MacKillop, Aaron C. Lim and Lara A. Ray

Improving Treatment Together: a protocol for a multi-phase, community-based participatory, and co-design project to improve youth opioid treatment service experiences in British Columbia

Opioid use is one of the most critical public health issues as highly potent opioids contribute to rising rates of accidental opioid-related toxicity deaths. This crisis has affected people from all age groups...

Authors: Kirsten Marchand, Corinne Tallon, Christina Katan, Jill Fairbank, Oonagh Fogarty, Katrina Marie Pellatt, Roxanne Turuba, Steve Mathias and Skye Barbic

‘Treat my whole person, not just my condition’: qualitative explorations of hepatitis C care delivery preferences among people who inject drugs

The advent of direct-acting antivirals (DAAs)—a form of hepatitis C (HCV) treatment associated with shorter treatment course and greater efficacy—offers an unprecedented opportunity to eliminate HCV, but only ...

Authors: Judith I. Tsui, Michael P. Barry, Elizabeth J. Austin, Elsa W. Sweek, Elyse Tung, Ryan N. Hansen, Michael Ninburg, John D. Scott, Sara N. Glick and Emily C. Williams

Fluctuations in barriers to medication treatment for opioid use disorder prescribing over the course of a one-year external facilitation intervention

The Veterans Health Administration (VHA) is invested in expanding access to medication treatment for opioid use disorder (MOUD) to save lives. Access varies across VHA facilities and, thus, requires implementa...

Authors: Allison M. Gustavson, Marie E. Kenny, Jennifer P. Wisdom, Hope A. Salameh, Princess E. Ackland, Adam J. Gordon and Hildi J. Hagedorn

Racial/ethnic equity in substance use treatment research: the way forward

Opioid use and opioid-related overdose continue to rise among racial/ethnic minorities. Social determinants of health negatively impact these communities, possibly resulting in poorer treatment outcomes. Resea...

Authors: Kathleen Burlew, Caravella McCuistian and José Szapocznik

Protecting patients and staff in residential treatment centers during exposure to COVID-19: commentary

The COVID-19 pandemic has created a crisis in access to addiction treatment. Programs with residential components have been particularly impacted as they try to keep infection from spreading in facilities and ...

Authors: Kimberly A. Johnson, Carolyn Keough, Holly Hills, Wouter Vermeer, Rebecca Lengnick-Hall, Moira McNulty, Mark McGovern and Hendricks Brown

“At least someone thinks I’m doing well”: a real-world evaluation of the quit-smoking app StopCoach for lower socio-economic status smokers

Smoking is more prevalent and persistent among lower socio-economic status (SES) compared with higher-SES groups, and contributes greatly to SES-based health inequities. Few interventions exist that effectivel...

Authors: Eline Meijer, Janneke S. Korst, Kristiene G. Oosting, Eline Heemskerk, Sander Hermsen, Marc C. Willemsen, Bas van den Putte, Niels H. Chavannes and Jamie Brown

Effects of morbidity on smoking cessation: a national smoking cessation program

In smokers with chronic diseases, we examined the abstinence rates over 6 months and its affecting factors in the context of the Korea National Health Insurance Service (NHIS) smoking cessation program.

Authors: Young-Gyun Seo, Min-Woo Jo, Yu-Jin Paek and Jaekyung Choi

Receipt of medications for opioid use disorder among youth engaged in primary care: data from 6 health systems

Little is known about prevalence and treatment of OUD among youth engaged in primary care (PC). Medications are the recommended treatment of opioid use disorder (OUD) for adolescents and young adults (youth). ...

Authors: Sarah M. Bagley, Laura Chavez, Jordan M. Braciszewski, Mary Akolsile, Denise M. Boudreau, Gwen Lapham, Cynthia I. Campbell, Gavin Bart, Bobbi Jo H. Yarborough, Jeffrey H. Samet, Andrew J. Saxon, Rebecca C. Rossom, Ingrid A. Binswanger, Mark T. Murphy, Joseph E. Glass and Katharine A. Bradley

Financial sustainability of payment models for office-based opioid treatment in outpatient clinics

Office-Based Opioid Treatment (OBOT) is a delivery model which seeks to make medications for opioid use disorder (MOUD), particularly buprenorphine, widely available in general medical clinics and offices. Des...

Authors: Dominic Hodgkin, Constance Horgan and Gavin Bart

Perceived family cohesion, social support, and quality of life in patients undergoing treatment for substance use disorders compared with patients with mental and physical disorders

Support from family and other social network elements can be important in helping patients to cope with practical and emotional consequences of diseases. The aim of the study was to examine perception of famil...

Authors: Bente Birkeland, Bente Weimand, Torleif Ruud, Darryl Maybery and John-Kåre Vederhus

Smoking cessation using preference-based tools: a mixed method pilot study of a novel intervention among smokers with low socioeconomic position

Compared to smokers with favorable socio-economic position (SEP), those with low SEP are less likely to have a successful smoking cessation attempt. Tailored approaches are therefore needed, and general practi...

Authors: Mégane Héron, Anne-Laurence Le Faou, Gladys Ibanez, Brigitte Métadieu, Maria Melchior and Fabienne El-Khoury Lesueur

Plausibility of patient-centred care in high-intensity methadone treatment: reflections of providers and patients

Patients with opioid use disorder (OUD) often have complex health care needs. Methadone is one of the medications for opioid use disorder (MOUD) used in the management of OUDs. Highly restrictive methadone tre...

Authors: Kerry Marshall, Geoffrey Maina and Jordan Sherstobitoff

Reimagining brief interventions for alcohol: towards a paradigm fit for the twenty first century?

There is no longer support for the idea that brief intervention programmes alone can contribute meaningfully to the improvement of population health relating to alcohol. As a result, calls for major innovation...

Authors: Jim McCambridge

Development of an unannounced standardized patient protocol to evaluate opioid use disorder treatment in pregnancy for American Indian and rural communities

Opioid use disorder (OUD) disproportionately impacts rural and American Indian communities and has quadrupled among pregnant individuals nationwide in the past two decades. Yet, limited data are available abou...

Authors: A. Taylor Kelley, Marcela C. Smid, Jacob D. Baylis, Elizabeth Charron, Amy E. Binns-Calvey, Shayla Archer, Saul J. Weiner, Lori Jo Begaye and Gerald Cochran

A Health Technician-delivered Brief Intervention linked to AUDIT for reduction of alcohol use in Chilean primary care: a randomized controlled trial

Because of the shortage of health professionals in Chilean primary care, Health Technicians (HT) are providing Brief Interventions (BI) for risky alcohol consumption. We compared the efficacy of two AUDIT-link...

Authors: Nicolas A. Barticevic, Fernando Poblete, Soledad M. Zuzulich, Victoria Rodriguez, Diego Quevedo, Brena F. Sena and Laura Bradshaw

What do clinicians want? Understanding frontline addiction treatment clinicians’ preferences and priorities to improve the design of measurement-based care technology

Measurement-based care (MBC) is the practice of routinely administering standardized measures to support clinical decision-making and monitor treatment progress. Despite evidence of its effectiveness, MBC is r...

Authors: Justin S. Tauscher, Eliza B. Cohn, Tascha R. Johnson, Kaylie D. Diteman, Richard K. Ries, David C. Atkins and Kevin A. Hallgren

A pilot study of the functionality and clinician acceptance of a clinical decision support tool to improve primary care of opioid use disorder

Most Americans with opioid use disorder (OUD) do not receive indicated medical care. A clinical decision support (CDS) tool for primary care providers (PCPs) could address this treatment gap. Our primary objec...

Authors: Rebecca C. Rossom, JoAnn M. Sperl-Hillen, Patrick J. O’Connor, A. Lauren Crain, Laurel Nightingale, Anne Pylkas, Kristen V. Huntley and Gavin Bart

Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: a systematic review

Opioid withdrawal symptoms prior to buprenorphine initiation may be intolerable and as a result, alternative strategies have emerged. We aim to systematically review the efficacy and safety of buprenorphine in...

Authors: K. K. Adams, M. Machnicz and D. M. Sobieraj

Should screening for risk of gambling-related harm be undertaken in health, care and support settings? A systematic review of the international evidence

Gambling-related harm is an increasing recognised problem internationally. Recent years have seen an explosion in opportunities to gamble, both in person and online. Health and other care settings have the pot...

Authors: Lindsay Blank, Susan Baxter, Helen Buckley Woods and Elizabeth Goyder

Facilitating rapid access to addiction treatment: a randomized controlled trial

Obtaining timely access to addiction medicine treatment for patients with substance use disorders is challenging and patients often have to navigate complex referral pathways. This randomized controlled trial ...

Authors: Anita Srivastava, Sarah Clarke, Kate Hardy and Meldon Kahan

Physician blame and vulnerability: novel predictors of physician willingness to work with patients who misuse opioids

Successfully combating the opioid crisis requires patients who misuse opioids to have access to affirming and effective health care. However, there is a shortage of physicians who are willing to work with thes...

Authors: Berkeley Franz, Lindsay Y. Dhanani and Daniel L. Brook

A medical peer-delivered intervention comprising brief motivational interviewing via instant-messaging interaction to reduce drug misuse among youth in Hong Kong: A protocol for a randomised controlled trial

Youth are frequently exposed to drugs, and most youth who misuse drugs are reluctant to seek help from services due to the worry of others being judgmental, lacking expertise, exposing their personal informati...

Authors: William Ho Cheung Li, Wei Xia, Laurie Long Kwan Ho, Ankie Tan Cheung, Queenie Kuai I. Leong and Tingna Liang

Patient outcomes and experience of a task-shared screening and brief intervention service for problem substance use in South African emergency centres: a mixed methods study

Screening, brief intervention and referral to treatment (SBIRT) programmes have resulted in generally positive outcomes in healthcare settings, particularly for problem alcohol use, yet implementation is hampe...

Authors: Claire van der Westhuizen, Megan Malan, Tracey Naledi, Marinda Roelofse, Bronwyn Myers, Dan J. Stein, Sa’ad Lahri and Katherine Sorsdahl

Housing, opportunities, motivation and engagement (HOME) for homeless youth at-risk for opioid use disorder: study protocol for a randomized controlled trial

Homeless youth experience high rates of substance use disorders, exposures to violence, mental and physical health conditions, and mortality. They have been particularly affected by the opioid crisis. However,...

Authors: Natasha Slesnick, Laura Chavez, Alicia Bunger, Ruri Famelia, Jodi Ford, Xin Feng, Sarah Higgins, Eugene Holowacz, Soren Jaderlund, Ellison Luthy, Allen Mallory, Jared Martin, Laura Walsh, Tansel Yilmazer and Kelly Kelleher

Staff experiences of encountering and treating outpatients with substance use disorder in the psychiatric context: a qualitative study

High comorbidity exists between mental illness and substance use disorders (SUD). Patients in psychiatry living with problematic alcohol or drug consumption can experience a sense of exclusion, where seeking h...

Authors: Elisabeth Petersén, Anna Thurang and Anne H. Berman

The NIDA clinical trials network: evolving, expanding, and addressing the opioid epidemic

Over the past two decades, the National Drug Abuse Treatment Clinical Trials Network (CTN), a program of the National Institute on Drug Abuse (NIDA), has expanded from the initial six Nodes to 16 Nodes, as a n...

Authors: Betty Tai, Ronald Dobbins, Quandra Blackeney, David Liu and Landhing Moran

Advancing a cascading train-the-trainer model of frontline HIV service providers in South Africa: protocol of an implementation trial

South Africa is marked by high rates of both HIV and alcohol use, and there is a detrimental synergistic relationship between these two epidemics. The Institute of Medicine recommends integrated care for alcoh...

Authors: Caroline C. Kuo, Goodman Sibeko, Morayo Akande, Shaheema Allie, Nurain Tisaker, Dan J. Stein and Sara J. Becker