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Table 2 Clinical decision support algorithm

From: Creation of an algorithm for clinical decision support for treatment of opioid use disorder with buprenorphine in primary care

Critical decision point

Critical status

Plan

Week 0 (CDP #1)

Symptomatic

Initiate buprenorphine treatment: adjust dose to lower end of therapeutic dose range

Week 2 (CDP #2)

Full response2

Continue current dose

Partial response

Continue current dose

OR

Increase dose3

Minimal or nonresponse

Increase dose

Week 4 (CDP #3)

Full response

Go to continuation phase if full response is sustained for at least 4 weeks. Otherwise, continue current does

Partial response

Increase dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Continue dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

Minimal or nonresponse

Increase dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Continue dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

Week 6 (CDP #4)

Full response

Go to continuation phase if full response is sustained for at least 4 weeks. Otherwise, continue current does

Partial response

Increase dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Divide daily dose in half, take medication BID and counsel regarding behaviors to support recovery (including mutual help group attendance)

Minimal or nonresponse

Increase dose and counsel regarding behaviors to support recovery (including mutual help group attendance) OR

Divide daily dose in half, take medication BID and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Refer to specialty care. Continue current dose until patient is evaluated by specialist

Week 8 (CDP #5)1

Full response

Go to continuation phase if full response is sustained for at least 4 weeks. Otherwise, continue current does

Partial response

Increase dose and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Divide daily dose in half, take medication BID and counsel regarding behaviors to support recovery (including mutual help group attendance)

Minimal or nonresponse

Divide daily dose in half, take medication BID and counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Refer to specialty care. Continue current dose until patient is evaluated by specialist

Week 10 (CDP #6)

Full response

Go to continuation phase if full response is sustained for at least 4 weeks. Otherwise, continue current does

Partial response

Increase dose

OR

Counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Refer to specialty care. Continue current dose until patient is evaluated by specialist

Minimal or nonresponse

Refer to specialty care. Continue current dose until patient is evaluated by specialist

Week 12 (CDP #7)

Full response

Go to continuation phase if full response is sustained for at least 4 weeks. Otherwise, continue current does

Partial response

Increase dose

OR

Counsel regarding behaviors to support recovery (including mutual help group attendance)

OR

Refer to specialty care. Continue current dose until patient is evaluated by specialist

Minimal or nonresponse

Refer to specialty care. Continue current dose until patient is evaluated by specialist

  1. 1For patients showing minimal or no response, total trial typically should not exceed 8 weeks.
  2. 2For patients with a partial response the trial may last up to 12 weeks to increase dose and implement counseling. Patients with only a partial response at any time point beyond 12 weeks should be considered for referral to specialty care. Minimal or nonresponse is < 25% decrease from baseline OR 25–75% decrease from baseline with use in past 2 weeks, partial response is 25–75% decrease from baseline OR > 75% decrease from baseline with use in past 2 weeks, and full response is > 75% decrease from baseline AND no use in past 2 weeks
  3. 3Per buprenorphine–naloxone SL package insert, dosages higher than 24 mg of buprenorphine-6 mg of naloxone have not demonstrated benefit. Maximum daily dose of buprenorphine not to exceed 24 mg