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Table 4 Summary of SNP outcome associations

From: A systematic review of GWAS identified SNPs associated with outcomes of medications for opioid use disorder

First author last name, year

Outcome

SNP ID

Chr:

position

Alleles

Minor allele

Gene

MAF

N

Measure of association

Measure of association value

Measure of variability

Measure of variability value

p-value

Ethnicity

Cox, 2020 [20]

NA

Nelson, 2016 [21]

Opioid dependence end point (daily heroin injection)

rs1436171

1:224881828

A/?

A

CNIH3

0.44

1167

OR

0.54

95% CI

0.42–0.68

6.26E-07

European

rs1369846

1:224894095

C/?

C

CNIH3

0.38

1167

OR

0.52

95% CI

0.41–0.66

9.42E-08

European

rs1436175

1:224908366

T/?

T

CNIH3

0.37

1167

OR

0.5

95% CI

0.39–0.64

2.72E-08

European

Smith, 2017 [22]

Methadone dose

rs73568641

6:154025139

C/T

C

OPRM1

0.1

383

β

0.6808

SE

0.1226

2.81E-08

African American

rs7451325

6:154016517

C/T

C

OPRM1

0.1

383

β

0.6807

SE

0.1226

2.83E-08

African American

rs111559266

6:153998560

A/G

A

OPRM1

0.1

383

β

0.6546

SE

0.1252

1.72E-07

African American

rs76499485

6:154004364

A/G

A

OPRM1

0.1

383

β

0.6487

SE

0.1257

2.48E-07

African American

rs7578347

2:13121168

T/C

T

TRIB2

0.43

383

β

0.3926

SE

0.0764

2.77E-07

African American

rs7578329

2:13121135

T/C

T

TRIB2

0.43

383

β

0.3924

SE

0.0764

2.81E-07

African American

rs13423393

2:13120763

T/C

T

TRIB2

0.43

383

β

0.3922

SE

0.0764

2.85E-07

African American

rs6745283

2:13120700

A/T

A

TRIB2

0.43

383

β

0.3923

SE

0.0765

2.93E-07

African American

rs73568677

6:154046471

T/C

T

OPRM1

0.09

383

β

0.6431

SE

0.1261

3.42E-07

African American

rs116777827

6:154084534

T/C

T

OPRM1

0.11

383

β

0.5981

SE

0.1176

3.64E-07

African American

rs4669899

2:13121465

T/C

T

TRIB2

0.41

383

β

0.3928

SE

0.0779

4.62E-07

African American

rs4669900

2:13121525

T/C

T

TRIB2

0.41

383

β

0.3925

SE

0.078

4.87E-07

African American

rs4669901

2:13121591

G/A

G

TRIB2

0.41

383

β

0.393

SE

0.0781

4.88E-07

African American

rs13397286

2:13120841

A/G

A

TRIB2

0.42

383

β

0.3926

SE

0.0781

5.01E-07

African American

rs12664381

6:154054500

T/C

T

OPRM1

0.11

383

β

0.5873

SE

0.1171

5.26E-07

African American

rs12527630

6:154064934

G/A

G

OPRM1

0.11

383

β

0.5868

SE

0.1172

5.50E-07

African American

rs73570652

6:154070563

T/C

T

OPRM1

0.11

383

β

0.5867

SE

0.1172

5.52E-07

African American

rs12663416

6:154057383

T/C

T

OPRM1

0.11

383

β

0.5856

SE

0.117

5.54E-07

African American

rs12104412

19:36731058

T/A

T

ZNF146

0.15

383

β

0.4939

SE

0.099

6.00E-07

African American

rs57072980

2:13122014

T/C

T

TRIB2

0.43

383

β

0.3823

SE

0.0772

7.36E-07

African American

rs9360217

6:67338593

G/T

G

EYS

0.22

1027

β

− 0.2613

SE

0.0525

6.55E-07

European American

rs9345875

6:67370087

G/T

G

EYS

0.21

1027

β

− 0.2602

SE

0.0524

6.95E-07

European American

rs9342570

6:67368858

A/T

A

EYS

0.21

1027

β

− 0.2589

SE

0.0523

7.53E-07

European American

rs9345867

6:67359694

C/T

C

EYS

0.21

1027

β

− 0.258

SE

0.0522

7.83E-07

European American

rs2045196

6:67339443

G/C

G

EYS

0.21

1027

β

− 0.265

SE

0.0537

8.15E-07

European American

rs1026388

6:67348220

A/C

A

EYS

0.21

1027

β

− 0.2576

SE

0.0523

8.55E-07

European American

rs4142573

6:67388037

T/C

T

EYS

0.21

1027

β

− 0.2561

SE

0.052

8.57E-07

European American

rs9363624

6:67387453

C/T

C

EYS

0.21

1027

β

− 0.2561

SE

0.052

8.57E-07

European American

rs9354462

6:67383719

T/C

T

EYS

0.21

1027

β

− 0.2565

SE

0.0521

8.64E-07

European American

rs9351587

6:67400119

T/C

T

EYS

0.21

1027

β

− 0.256

SE

0.052

8.65E-07

European American

rs4710324

6:67352212

T/C

T

EYS

0.21

1027

β

− 0.2574

SE

0.0523

8.72E-07

European American

rs9342572

6:67386966

T/C

T

EYS

0.21

1027

β

− 0.2574

SE

0.0523

8.72E-07

European American

rs4710621

6:67389232

G/A

G

EYS

0.21

1027

β

− 0.2559

SE

0.052

8.74E-07

European American

rs2124198

6:67366749

C/T

C

EYS

0.21

1027

β

− 0.2567

SE

0.0522

8.89E-07

European American

rs9345880

6:67391212

C/T

C

EYS

0.21

1027

β

− 0.2556

SE

0.052

9.00E-07

European American

rs9360224

6:67397651

T/C

T

EYS

0.21

1027

β

− 0.2553

SE

0.052

9.26E-07

European American

rs2124199

6:67391889

A/T

A

EYS

0.21

1027

β

− 0.2539

SE

0.0518

9.65E-07

European American

Wang, 2018 [23]

NA

Yang, 2016 [24]

Plasma concentration of R-methadone

rs17180299

9:NA

A/G

G

intergenic

0.09

344

β

NA

NA

NA

2.24E-08

Han Chinese

Plasma concentration of S-methadone

AX-16534452

11:NA

NA

NA

SPON1

NA

344

β

NA

NA

NA

4.83E-07

Han Chinese

Plasma concentration of R-EDDP

rs1448332

3:NA

NA

NA

intergenic

NA

344

β

NA

NA

NA

8.18E-07

Han Chinese

  1. Chr is the chromosome number, and position refers to the SNP position on the respective chromosome. MAF is the reported minor allele frequency, N is the sample size of the analyzed population, and Outcome is the phenotype associated with the SNP. β refers to the beta coefficient, OR the odds ratio, SE the standard error, and 95% CI to the 95% confidence intervals reported. NA was used to designate missing information
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Addiction Science & Clinical Practice

ISSN: 1940-0640