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Table 1 Symptom-triggered IV fentanyl induction orders

From: Case report: acute care management of severe opioid withdrawal with IV fentanyl

Phases

Medication

Monitoring

Pre-induction

Discontinue all opioids

 

Induction

Fentanyl 100–200 mcg IV q5min until patient satisfaction and RASS 0/−1

COWS before/after induction

RASS, vitals* after each dose

Maintenance (0–24 h post-induction)

Fentanyl X mcg IV q1h PRN to maintain patient comfort and RASS 0/−1, where X is 50% of cumulative induction dose

RASS, vitals* q1h

Continuous ECG and oxygen saturation monitoring

Consolidation (24 h + post-induction)

Reduced frequency of dosing on consecutive days to q2h, q3h, q4h PRN, where fentanyl dose is calculated using 24 h cumulative dose divided by dosing frequency

RASS, vitals* q1h

Continuous ECG and oxygen saturation monitoring

Oversedation (RASS ≤ -2)

Naloxone 0.1 mg IV push q2min PRN until patient awakens

RASS, vitals* q1h

Continuous ECG and oxygen saturation monitoring

  1. q_mins: every_minutes; q_h: every_hour; prn: as needed; IV: intravenous; RASS: Richmond Agitation-Sedation Scale; COWS: Clinical Opiate Withdrawal Score; mg: milligram; mcg: microgram
  2. *Vitals: heart rate, blood pressure, respiratory rate, oxygen saturation