Articles

Under one roof: identification, evaluation, and treatment of chronic hepatitis C in addiction care

For over a decade, the vast majority of new hepatitis C virus (HCV) infections have been among young people who inject drugs (PWID). Well-characterized gaps in chronic HCV diagnosis, evaluation, and treatment ...

Authors: Stephen A. Martin, Jordon Bosse, Amanda Wilson, Phyllis Losikoff and Lisa Chiodo

Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research

Contemporary advances in addiction neuroscience have paralleled increasing interest in the ancient mental training practice of mindfulness meditation as a potential therapy for addiction. In the past decade, ...

Authors: Eric L. Garland and Matthew O. Howard

Barriers and facilitators affecting the implementation of substance use screening in primary care clinics: a qualitative study of patients, providers, and staff

Alcohol and drug use are leading causes of morbidity and mortality that frequently go unidentified in medical settings. As part of a multi-phase study to implement electronic health record-integrated substanc...

Authors: Jennifer McNeely, Pritika C. Kumar, Traci Rieckmann, Erica Sedlander, Sarah Farkas, Christine Chollak, Joseph L. Kannry, Aida Vega, Eva A. Waite, Lauren A. Peccoralo, Richard N. Rosenthal, Dennis McCarty and John Rotrosen

Adherence intervention for HIV-infected persons who use drugs: adaptation, open trial, and pilot randomized hybrid type 1 trial protocol

HIV-infected people who use drugs (PWUD) exhibit the highest rates of non-adherence to antiretroviral therapy (ART) among people living with HIV. This contributes to poor treatment outcomes, increased morbidit...

Authors: Kasey Claborn, Sara Becker, Don Operario, Steve Safren, Josiah D. Rich and Susan Ramsey

Evaluation of the effect of methamphetamine on traumatic injury complications and outcomes

This study investigates the impact of methamphetamine use on trauma patient outcomes.

Authors: Michael M. Neeki, Fanglong Dong, Lidia Liang, Jake Toy, Braeden Carrico, Nina Jabourian, Arnold Sin, Farabi Hussain, Sharon Brown, Keyvan Safdari, Rodney Borger and David Wong

Standardised alcohol screening in primary health care services targeting Aboriginal and Torres Strait Islander peoples in Australia

Aboriginal and Torres Strait Islander Community Controlled Health Services (ACCHSs) around Australia have been asked to standardise screening for unhealthy drinking. Accordingly, screening with the 3-item AUD...

Authors: M. Mofizul Islam, Helen T. Oni, K. S. Kylie Lee, Noel Hayman, Scott Wilson, Kristie Harrison, Beth Hummerston, Rowena Ivers and Katherine M. Conigrave

How do people with mood and anxiety disorders perceive and interpret the Drinking Motives Questionnaire? A think-aloud study in a clinical setting

Research has identified drinking motives as the final common pathway to alcohol use, and associations between specific drinking motives and drinking patterns have consistently been demonstrated. Data on drinki...

Authors: Christina Nehlin, Margareta Wennberg and Caisa Öster

Substance use and the HIV care continuum: important advances

Authors: P. Todd Korthuis and E. Jennifer Edelman

Development and differentiability of three brief interventions for risky alcohol use that include varying doses of motivational interviewing

While brief intervention (BI) for risky alcohol use generally yields positive effects among those identified by screening, effect sizes are small and there is unexplained heterogeneity in outcome. The heterog...

Authors: Jennifer E. Hettema, Stephanie A. Cockrell, Abigail Reeves, Karen S. Ingersoll, Paula J. Lum, Richard Saitz, Cristina M. Murray-Krezan and Valerie A. Carrejo

Correction to: Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial

Upon publication of the original article

Authors: Bryan R. Garner, Heather J. Gotham, Stephen J. Tueller, Elizabeth L. Ball, David Kaiser, Patricia Stilen, Kathryn Speck, Denna Vandersloot, Traci R. Rieckmann, Michael Chaple, Erika G. Martin and Steve Martino

Eligibility for heroin-assisted treatment (HAT) among people who inject opioids and are living with HIV in a Canadian setting

A growing body of evidence supports the effectiveness of injectable diacetylmorphine (i.e., heroin) for individuals with treatment-refractory opioid use disorder. Despite this evidence, and the increasing toll...

Authors: Jan Klimas, Huiru Dong, Nadia Fairbairn, Eugenia Socías, Rolando Barrios, Evan Wood, Thomas Kerr, Julio Montaner and M.-J. Milloy

Racial/ethnic differences in the association between alcohol use and mortality among men living with HIV

Increasing alcohol use is associated with increased risk of mortality among patients living with HIV (PLWH). This association varies by race/ethnicity among general outpatients, but racial/ethnic variation ha...

Authors: Kara M. Bensley, Kathleen A. McGinnis, David A. Fiellin, Adam J. Gordon, Kevin L. Kraemer, Kendall J. Bryant, E. Jennifer Edelman, Stephen Crystal, Julie R. Gaither, P. Todd Korthuis, Brandon D. L. Marshall, India J. Ornelas, K. C. Gary Chan, Julia C. Dombrowski, John C. Fortney, Amy C. Justice…

Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety, depression, fitness and quality of life in adults with previous methamphetamine dependency: a systematic review

Methamphetamine (MA) is a highly addictive psychostimulant used by approximately 52 million people worldwide. Chronic MA abuse leads to detrimental physiological and neurological changes, as well as increases ...

Authors: Linzette Morris, Jessica Stander, Wardah Ebrahim, Stephanie Eksteen, Orissa Anna Meaden, Ané Ras and Annemarie Wessels

Substance use patterns and in-hospital care of adolescents and young adults attending music concerts

Few studies describe medical complaints and substance use patterns related to attending music concerts. As such, the objective of this study is to describe patient demographics, substance use and intoxication ...

Authors: Stephanie M. Ruest, Alexander M. Stephan, Peter T. Masiakos, Paul D. Biddinger, Carlos A. Camargo and Sigmund Kharasch

Developing adaptive interventions for adolescent substance use treatment settings: protocol of an observational, mixed-methods project

Over 1.6 million adolescents in the United States meet criteria for substance use disorders (SUDs). While there are promising treatments for SUDs, adolescents respond to these treatments differentially in part...

Authors: Sean Grant, Denis Agniel, Daniel Almirall, Q. Burkhart, Sarah B. Hunter, Daniel F. McCaffrey, Eric R. Pedersen, Rajeev Ramchand and Beth Ann Griffin

Changes in Specific Substance Involvement Scores among SBIRT recipients in an HIV primary care setting

Substance use is common among people living with HIV (PLHIV) and is associated with worse outcomes along the HIV care continuum. One potentially effective clinic-based approach to addressing unhealthy substanc...

Authors: Carol Dawson-Rose, Jessica E. Draughon, Yvette Cuca, Roland Zepf, Emily Huang, Bruce A. Cooper and Paula J. Lum

Delivery of screening and brief intervention for unhealthy alcohol use in an urban academic Federally Qualified Health Center

Screening and brief intervention (SBI) for unhealthy drinking has not been widely implemented in primary care partly due to reliance on physicians to perform it.

Authors: Marcus A. Bachhuber, Megan A. O’Grady, Henry Chung, Charles J. Neighbors, Joseph DeLuca, Elenita M. D’Aloia, Arelis Diaz and Chinazo O. Cunningham

Patterns of HIV testing, drug use, and sexual behaviors in people who use drugs: findings from a community-based outreach program in Phnom Penh, Cambodia

People who use drugs are an important priority for HIV programs. However, data related to their utilization of HIV services are limited. This paper reports patterns of HIV testing, drug use, and risk and servi...

Authors: Gitau Mburu, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Khuondyla Pal and Siyan Yi

Role of substance use in HIV care cascade outcomes among people who inject drugs in Russia

Engaging people who drink alcohol or inject drugs in HIV care can be challenging, particularly in Eastern Europe. Healthcare facilities in Russia are organized by specialty; therefore linking patients from add...

Authors: Bulat Idrisov, Karsten Lunze, Debbie M. Cheng, Elena Blokhina, Natalia Gnatienko, Emily Quinn, Carly Bridden, Alexander Y. Walley, Kendall J. Bryant, Dmitry Lioznov, Evgeny Krupitsky and Jeffrey H. Samet

Screening in Trauma for Opioid Misuse Prevention (STOMP): study protocol for the development of an opioid risk screening tool for victims of injury

Opioid addiction and overdose are epidemic in the U.S. Victims of traumatic injury are at greater than average risk for opioid misuse and related complications. Potential risk screens and preventive intervent...

Authors: Randall Brown, Brienna Deyo, Chelsea Riley, Andrew Quanbeck, Joseph E. Glass, Rebecca Turpin, Scott Hetzel, Christopher Nicholas, Maireni Cruz and Suresh Agarwal

Testing the implementation and sustainment facilitation (ISF) strategy as an effective adjunct to the Addiction Technology Transfer Center (ATTC) strategy: study protocol for a cluster randomized trial

Improving the extent to which evidence-based practices (EBPs)—treatments that have been empirically shown to be efficacious or effective—are integrated within routine practice is a well-documented challenge ac...

Authors: Bryan R. Garner, Mark Zehner, Mathew R. Roosa, Steve Martino, Heather J. Gotham, Elizabeth L. Ball, Patricia Stilen, Kathryn Speck, Denna Vandersloot, Traci R. Rieckmann, Michael Chaple, Erika G. Martin, David Kaiser and James H. Ford II

Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial

In 2010, the first comprehensive National HIV/AIDS Strategy for the United States was released and included three goals: (1) reducing the number of people who become infected with HIV, (2) increasing access to...

Authors: Bryan R. Garner, Heather J. Gotham, Stephen J. Tueller, Elizabeth L. Ball, David Kaiser, Patricia Stilen, Kathryn Speck, Denna Vandersloot, Traci R. Rieckmann, Michael Chaple, Erika G. Martin and Steve Martino

More beds are not the answer: transforming detoxification units into medication induction centers to address the opioid epidemic

Authors: Peter D. Friedmann and Joji Suzuki

Factors influencing the long-term sustainment of quality improvements made in addiction treatment facilities: a qualitative study

A greater understanding of the factors that influence long-term sustainment of quality improvement (QI) initiatives is needed to promote organizational ability to sustain QI practices over time, help improve f...

Authors: Scott P. Stumbo, James H. Ford II and Carla A. Green

Convenience without disclosure: a formative research study of a proposed integrated methadone and antiretroviral therapy service delivery model in Dar es Salaam, Tanzania

Though timely initiation of antiretroviral therapy (ART) is a vital component of effective HIV prevention, care and treatment, people who inject drugs are less likely to receive ART than their non-drug using c...

Authors: Alexis Cooke, Haneefa Saleem, Dorothy Mushi, Jessie Mbwambo, Saria Hassan and Barrot H. Lambdin

Barriers and facilitators of the HIV care continuum in Southern New England for people with drug or alcohol use and living with HIV/AIDS: perspectives of HIV surveillance experts and service providers

Contemporary studies about HIV care continuum (HCC) outcomes within substance using populations primarily focus on individual risk factors rather than provider- or systems-level influences. Over 25% of people...

Authors: Lauretta E. Grau, Abbie Griffiths-Kundishora, Robert Heimer, Marguerite Hutcheson, Amy Nunn, Caitlin Towey and Thomas J. Stopka

Alcohol consumption patterns and HIV viral suppression among persons receiving HIV care in Florida: an observational study

Alcohol consumption has been associated with poor antiretroviral therapy (ART) adherence but less is known about its relationship to HIV viral suppression, or whether certain drinking patterns have a stronger ...

Authors: R. L. Cook, Z. Zhou, N. E. Kelso-Chichetto, J. Janelle, J. P. Morano, C. Somboonwit, W. Carter, G. E. Ibanez, N. Ennis, C. L. Cook, R. A. Cohen, B. Brumback and K. Bryant

Barriers and facilitators to implementing addiction medicine fellowships: a qualitative study with fellows, medical students, residents and preceptors

Although progress in science has driven advances in addiction medicine, this subject has not been adequately taught to medical trainees and physicians. As a result, there has been poor integration of evidence-...

Authors: J. Klimas, W. Small, K. Ahamad, W. Cullen, A. Mead, L. Rieb, E. Wood and R. McNeil

Proceedings of the 14th annual conference of INEBRIA

Authors: Aisha S. Holloway, Jennifer Ferguson, Sarah Landale, Laura Cariola, Dorothy Newbury-Birch, Amy Flynn, John R. Knight, Lon Sherritt, Sion K. Harris, Amy J. O’Donnell, Eileen Kaner, Barbara Hanratty, Amy M. Loree, Kimberly A. Yonkers, Steven J. Ondersma, Kate Gilstead-Hayden…

HIV treatment cascade among female entertainment and sex workers in Cambodia: impact of amphetamine use and an HIV prevention program

HIV prevalence remains high in Cambodia among female entertainment and sex workers (FESW), and amphetamine-type stimulant (ATS) use significantly increases risk of infection. A successful continuum of care (Co...

Authors: Sokunny Muth, Aynar Len, Jennifer L. Evans, Maly Phou, Sophal Chhit, Yuthea Neak, Song Ngak, Ellen S. Stein, Adam W. Carrico, Lisa Maher and Kimberly Page

Integrated HIV care is associated with improved engagement in treatment in an urban methadone clinic

Persons living with HIV and unhealthy substance use are often less engaged in HIV care, have higher morbidity and mortality and are at increased risk of transmitting HIV to uninfected partners. We developed a ...

Authors: Claire Simeone, Brad Shapiro and Paula J. Lum

Screening, treatment initiation, and referral for substance use disorders

Substance use remains a leading cause of preventable death globally. A model of intervention known as screening, brief intervention, and referral to treatment (SBIRT) was developed decades ago to facilitate ti...

Authors: Steven L. Bernstein and Gail D’Onofrio

Comparison of DSM-IV and DSM-5 criteria for alcohol use disorders in VA primary care patients with frequent heavy drinking enrolled in a trial

Criteria for alcohol use disorders (AUD) in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) were intended to result in a similar prevalence of AUD as DSM-IV. We evaluated the pre...

Authors: Traci Takahashi, Gwen Lapham, Laura J. Chavez, Amy K. Lee, Emily C. Williams, Julie E. Richards, Diane Greenberg, Anna Rubinsky, Douglas Berger, Eric J. Hawkins, Joseph O. Merrill and Katharine A. Bradley

Enhancing patient navigation to improve intervention session attendance and viral load suppression of persons with HIV and substance use: a secondary post hoc analysis of the Project HOPE study

Interventions are needed to improve viral suppression rates among persons with HIV and substance use. A 3-arm randomized multi-site study (Metsch et al. in JAMA 316:156–70, 2016) was conducted to evaluate the ef...

Authors: Maxine Stitzer, Tim Matheson, Colin Cunningham, James L. Sorensen, Daniel J. Feaster, Lauren Gooden, Alexis S. Hammond, Heather Fitzsimons and Lisa R. Metsch

Associations of criminal justice and substance use treatment involvement with HIV/HCV testing and the HIV treatment cascade among people who use drugs in Oakland, California

People who smoke crack cocaine and people who inject drugs are at-risk for criminal justice involvement as well as HIV and HCV infection. Compared to criminal justice involvement, substance use treatment (SUT)...

Authors: Barrot H. Lambdin, Alex H. Kral, Megan Comfort, Andrea M. Lopez and Jennifer Lorvick

Patient-centered primary care for adults at high risk for AUDs: the Choosing Healthier Drinking Options In primary CarE (CHOICE) trial

Most patients with alcohol use disorders (AUDs) never receive alcohol treatment, and experts have recommended management of AUDs in primary care. The Choosing Healthier Drinking Options In primary CarE (CHOICE...

Authors: Katharine A. Bradley, Evette Joy Ludman, Laura J. Chavez, Jennifer F. Bobb, Susan J. Ruedebusch, Carol E. Achtmeyer, Joseph O. Merrill, Andrew J. Saxon, Ryan M. Caldeiro, Diane M. Greenberg, Amy K. Lee, Julie E. Richards, Rachel M. Thomas, Theresa E. Matson, Emily C. Williams, Eric Hawkins…

Rethinking alcohol interventions in health care: a thematic meeting of the International Network on Brief Interventions for Alcohol & Other Drugs (INEBRIA)

In 2016, the International Network on Brief Interventions for Alcohol & Other Drugs convened a meeting titled “Rethinking alcohol interventions in health care”. The aims of the meeting were to synthesize recen...

Authors: Joseph E. Glass, Sven Andréasson, Katharine A. Bradley, Sara Wallhed Finn, Emily C. Williams, Ann-Sofie Bakshi, Antoni Gual, Nick Heather, Marcela Tiburcio Sainz, Vivek Benegal and Richard Saitz

Seek, test, treat: substance-using women in the HIV treatment cascade in South Africa

Women in South Africa who use alcohol and other drugs face multiple barriers to HIV care. These barriers make it difficult for women to progress through each step in the HIV treatment cascade from diagnosis to...

Authors: Wendee M. Wechsberg, Charles van der Horst, Jacqueline Ndirangu, Irene A. Doherty, Tracy Kline, Felicia A. Browne, Jennifer M. Belus, Robin Nance and William A. Zule

Acceptability of a mobile health intervention to enhance HIV care coordination for patients with substance use disorders

Persons living with HIV and substance use disorders face barriers to sustained engagement in medical care, leading to suboptimal antiretroviral treatment outcomes. Innovative mobile technology tools such as cu...

Authors: Ryan P. Westergaard, Andrew Genz, Kristen Panico, Pamela J. Surkan, Jeanne Keruly, Heidi E. Hutton, Larry W. Chang and Gregory D. Kirk

VA residential substance use disorder treatment program providers’ perceptions of facilitators and barriers to performance on pre-admission processes

In the U.S. Department of Veterans Affairs (VA), residential treatment programs are an important part of the continuum of care for patients with a substance use disorder (SUD). However, a limited number of pro...

Authors: Laura S. Ellerbe, Luisa Manfredi, Shalini Gupta, Tyler E. Phelps, Thomas R. Bowe, Anna D. Rubinsky, Jennifer L. Burden and Alex H. S. Harris

The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy

Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiat...

Authors: Leen Naji, Brittany Burns Dennis, Monica Bawor, Michael Varenbut, Jeff Daiter, Carolyn Plater, Guillaume Pare, David C. Marsh, Andrew Worster, Dipika Desai, James MacKillop, Lehana Thabane and Zainab Samaan

Mobile technology intervention to improve care coordination between HIV and substance use treatment providers: development, training, and evaluation protocol

People living with HIV (PLWH) with a substance use disorder (SUD) tend to receive inadequate medical care in part because of a siloed healthcare system in which HIV and substance use services are delivered sep...

Authors: Kasey Claborn, Sara Becker, Susan Ramsey, Josiah Rich and Peter D. Friedmann

Public sector low threshold office-based buprenorphine treatment: outcomes at year 7

Buprenorphine maintenance for opioid dependence remains of limited availability among underserved populations, despite increases in US opioid misuse and overdose deaths. Low threshold primary care treatment mo...

Authors: Elenore Patterson Bhatraju, Ellie Grossman, Babak Tofighi, Jennifer McNeely, Danae DiRocco, Mara Flannery, Ann Garment, Keith Goldfeld, Marc N. Gourevitch and Joshua D. Lee

A systematic review of health economic models of opioid agonist therapies in maintenance treatment of non-prescription opioid dependence

Opioid dependence is a chronic condition with substantial health, economic and social costs. The study objective was to conduct a systematic review of published health-economic models of opioid agonist therapy...

Authors: Mersha Chetty, James J. Kenworthy, Sue Langham, Andrew Walker and William C. N. Dunlop

Prenatal treatment for opioid dependency: observations from a large inner-city clinic

The objective of this study was to review changes in the prevalence of opioid use disorder in pregnancy, and to describe the prenatal care and neonatal outcomes following the implementation of buprenorphine tr...

Authors: Kelley Saia, Sarah M. Bagley, Elisha M. Wachman, Payal P. Patel, Marisa D. Nadas and Susan B. Brogly

Opioid overdose prevention and naloxone rescue kits: what we know and what we don’t know

The opioid use and overdose crisis is persistent and dynamic. Opioid overdoses were initially driven in the 1990s and 2000s by the increasing availability and misuse of prescription opioids. More recently, opi...

Authors: Todd Kerensky and Alexander Y. Walley

Prevalence and factors associated with use of khat: a survey of patients entering HIV treatment programs in Ethiopia

Khat, a plant native to East Africa, has psychoactive constituents similar to amphetamine. Chronic khat use can lead to psychological dependence with multiple physical and mental health harms, complicating cli...

Authors: Alan R. Lifson, Sale Workneh, Tibebe Shenie, Desalegn Admassu Ayana, Zenebe Melaku, Lemlem Bezabih, Hiwot Tekle Waktola, Behailu Dagne, Rose Hilk, Ken C. Winters and Lucy Slater

Validation of the AUDIT-C in adults seeking help with their drinking online

The abbreviated Alcohol Use Disorder Identification Test for Consumption (AUDIT-C) is rapidly becoming the alcohol screening tool of choice for busy practitioners in clinical settings and by researchers keen t...

Authors: Zarnie Khadjesari, Ian R. White, Jim McCambridge, Louise Marston, Paul Wallace, Christine Godfrey and Elizabeth Murray

Technology-assisted intervention for parents of adolescents in residential substance use treatment: protocol of an open trial and pilot randomized trial

Adolescents in residential substance use disorder (SUD) treatment have poor outcomes post-discharge, with follow-up studies suggesting that most adolescents relapse within 90 days. Parenting practices directly...

Authors: Sara J. Becker, Lynn Hernandez, Anthony Spirito and Selby Conrad

Alcohol use in opioid agonist treatment

Alcohol misuse among individuals receiving agonist treatment for an opioid use disorder is common and is associated with significant morbidity and mortality. At present, though substantial research highlights ...

Authors: Seonaid Nolan, Jan Klimas and Evan Wood